International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors

MP Caulfield, NJM Birdsall - Pharmacological reviews, 1998 - ASPET
Actions of acetylcholine in the periphery are the result of activation of either the ionotropic
nicotinic receptor or the metabotropic muscarinic receptor. In the mammalian central
nervous system (CNS) c, both nicotinic and muscarinic receptor subtypes are present on …

JM Baldwin, GFX Schertler, VM Unger - Journal of molecular biology, 1997 - Elsevier
A model for the alpha-carbon positions in the seven transmembrane helices in the
rhodopsin family of G-protein-coupled receptors is presented. The model incorporates
structural information derived from the analysis of∼ 500 sequences in this family. The …

SK Shenoy, MT Drake, CD Nelson, DA Houtz… - Journal of Biological …, 2006 - ASBMB
Physiological effects of β adrenergic receptor (β2AR) stimulation have been classically
shown to result from G s-dependent adenylyl cyclase activation. Here we demonstrate a
novel signaling mechanism wherein β-arrestins mediate β2AR signaling to extracellular …

AC Kruse, J Hu, AC Pan, DH Arlow, DM Rosenbaum… - Nature, 2012 -
Acetylcholine, the first neurotransmitter to be identified 1, exerts many of its physiological
actions via activation of a family of G-protein-coupled receptors (GPCRs) known as
muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1–M5) …

J Wess - Critical Reviews™ in Neurobiology, 1996 -
Following the molecular cloning of five distinct muscarinic acetylcholine receptor (mAChR)
genes, the last decade has witnessed an explosion of new knowledge about how mAChRs
function at a molecular level. These studies have been greatly facilitated by the molecular …

J Wess - Pharmacology & therapeutics, 1998 - Elsevier
Molecular cloning studies have shown that G-protein-coupled receptors form one of the
largest protein families found in nature, and it is estimated that approximately 1000 different
such receptors exist in mammals. Characteristically, when activated by the appropriate …

CM Niswender, SC Copeland, K Herrick-Davis… - Journal of Biological …, 1999 - ASBMB
RNA transcripts encoding the serotonin 5-hydroxytryptamine 2C (5-HT 2C) receptor (5-HT
2C R) undergo adenosine-to-inosine RNA editing events at up to five specific sites.
Compared with rat brain, human brain samples expressed higher levels of RNA transcripts …

T Gudermann, T Schöneberg… - Annual review of …, 1997 -
▪ Abstract A prerequisite for the maintenance of homeostasis in a living organism is fine-
tuned communication between different cells. The majority of extracellular signaling
molecules, such as hormones and neurotransmitters, interact with a three-protein …

CM Niswender, K Herrick-Davis, GE Dilley… - …, 2001 - Elsevier
RNA encoding the human serotonin 5-HT 2C receptor (5-HT 2C R) undergoes adenosine-to-
inosine RNA editing events at five positions, resulting in an alteration of amino acids in the
second intracellular loop. Several edited 5-HT 2C Rs possess a reduced G-protein coupling …

J Liu, BR Conklin, N Blin, J Yun… - Proceedings of the …, 1995 - National Acad Sciences
Each G protein-coupled receptor recognizes only a distinct subset of the many structurally
closely related G proteins expressed within a cell. How this selectively is achieved at a
molecular level is not well understood, particularly since no specific point-to-point  …