M Nishimura, M Kakizaki, Y Ono, K Morimoto… - Journal of Biological …, 2002 - ASBMB
Tight junctions (TJs) consist of transmembrane proteins and many peripheral membrane
proteins. To further characterize the molecular organization of TJs, we attempted here to
screen for novel TJ proteins by the fluorescence localization-based expression cloning …

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KM Patrie - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2005 - Elsevier
The membrane-associated guanylate kinase protein, MAGI-1, has been shown to be a
component of epithelial tight junctions in both Madin–Darby canine kidney cells and in
intestinal epithelium. Because we have previously observed MAGI-1 expression in …

J Moreau, M Lord, M Boucher, P Belleau… - Gene, 2005 - Elsevier
The motin family of proteins is comprised of three polypeptides, angiomotin, angiomotin-like
1, and angiomotin-like 2. Angiomotin is an angiostatin-binding protein that promotes
endothelial cell motility and is involved in angiogenesis. The function of human angiomotin …

H Kawabe, H Nakanishi, M Asada, A Fukuhara… - Journal of Biological …, 2001 - ASBMB
Tight junctions (TJs) serve as a barrier that prevents solutes and water from passing through
the paracellular pathway, and as a fence between the apical and basolateral plasma
membranes in epithelial cells. TJs consist of transmembrane proteins (claudin, occludin, and …

A Bratt, WJ Wilson, B Troyanovsky, K Aase, R Kessler… - Gene, 2002 - Elsevier
Angiomotin has previously been identified in a yeast two-hybrid screen by its ability to bind
to angiostatin, an inhibitor of novel formation of blood vessels (angiogenesis). Angiomotin
mediates the inhibitory effect of angiostatin on endothelial cell migration and tube formation …

Y Sugihara‐Mizuno, M Adachi, Y Kobayashi… - Genes to …, 2007 - Wiley Online Library
We have previously shown that MUPP1, which has an MRE domain and 13 PDZ domains, is
expressed in epithelial cells and localize at tight junctions (TJs) and apical membranes.
Using yeast two‐hybrid screening, we found here that MUPP1 interacts with angiomotin …

T Levchenko, K Aase, B Troyanovsky, A Bratt… - Journal of cell …, 2003 - jcs.biologists.org
We have recently identified a novel protein, named angiomotin, by its ability to bind the
angiogenesis inhibitor angiostatin in the yeast two-hybrid system. Angiomotin belongs to a
family with two other members, AmotL-1 and-2 characterized by coiled-coil and C-terminal …

M Ernkvist, K Aase, C Ukomadu… - The FEBS …, 2006 - Wiley Online Library
Angiomotin, an 80 kDa protein expressed in endothelial cells, promotes cell migration and
invasion, and stabilizes tube formation in vitro. Angiomotin belongs to a new protein family
with two additional members, Amotl‐1 and Amotl‐2, which are characterized by conserved …

Y Zheng, S Vertuani, S Nyström, S Audebert… - Circulation …, 2009 - Am Heart Assoc
Rationale: We have previously shown that angiomotin (Amot) is essential for endothelial cell
migration during mouse embryogenesis. However,≈ 5% of Amot knockout mice survived
without any detectable vascular defects. Angiomotin-like protein 1 (AmotL1) potentially …

A Bratt, O Birot, I Sinha, N Veitonmäki, K Aase… - Journal of Biological …, 2005 - ASBMB
We have previously identified angiomotin by its ability to bind to and mediate the anti-
angiogenic properties of angiostatin. In vivo and in vitro data indicate an essential role of
angiomotin in endothelial cell motility. Here we show that angiostatin binds angiomotin on …