Volume 57, Issue 8
Review

Lipidomics of essential fatty acids and oxygenated metabolites

Michel Lagarde

Corresponding Author

Université de Lyon, UMR 1060 Inserm, IMBL, INSA‐Lyon, Villeurbanne, France

Correspondence: Professor Michel Lagarde, UMR 1060 Inserm (CarMeN), Bldg Pasteur‐IMBL, 20 Avenue A. Einstein, 69621 Villeurbanne, INSA‐Lyon, France

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Fax: +33‐4‐72‐43‐85‐24

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Nathalie Bernoud‐Hubac

Université de Lyon, UMR 1060 Inserm, IMBL, INSA‐Lyon, Villeurbanne, France

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Catherine Calzada

Université de Lyon, UMR 1060 Inserm, IMBL, INSA‐Lyon, Villeurbanne, France

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Evelyne Véricel

Université de Lyon, UMR 1060 Inserm, IMBL, INSA‐Lyon, Villeurbanne, France

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Michel Guichardant

Université de Lyon, UMR 1060 Inserm, IMBL, INSA‐Lyon, Villeurbanne, France

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First published: 01 July 2013
Cited by: 18

Abstract

Polyunsaturated fatty acids in mammals may be oxygenated into a myriad of bioactive products through di‐ and monooxygenases, products that are rapidly degraded to control their action. To evaluate the phenotypes of biological systems regarding this wide family of compounds, a lipidomics approach in function of time and compartments would be relevant. The current review takes into consideration most of the diverse oxygenated metabolites of essential fatty acids at large and their immediate degradation products. Their biological function and life span are considered. Overall, this is a fluxolipidomics approach that is emerging.

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