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Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura

List of authors.
  • Joel L. Moake, M.D.,
  • Christine K. Rudy,
  • Joseph H. Troll,
  • Mark J. Weinstein, Ph.D.,
  • Noreen M. Colannino,
  • José Azocar, M.D., D.Sc.,
  • Richard H. Seder, M.D.,
  • Suchen L. Hong, Ph.D.,
  • and Daniel Deykin, M.D.

This article has no abstract; the first 100 words appear below.

A platelet-agglutinating factor has been detected in the plasma of some patients during episodes of thrombotic thrombocytopenic purpura (TTP).1 , 2 Agglutination induced in vitro by this plasma factor is inhibited by normal plasma and does not require platelet production of the arachidonic acid metabolite thromboxane A2, release of granule contents, platelet metabolism, or calcium or magnesium ions.3 These characteristics are similar to those of agglutination induced in vitro by the attachment to platelets of large, multimeric, von Willebrand factor components of the factor VIII complex (VIII:vWF), and this similarity led us in the present study to investigate the properties . . .

Funding and Disclosures

Supported by research funds from the Veterans Administration and by grants (HL 223558 and HL 13262) from the National Institutes of Health.

We are indebted to Jan Mouché, R.N., Dr. John J. Byrnes, and Dr. Jefferson D. Upshaw, who provided plasma samples from their patients; to Dr. Oscar D. Ratnoff, who referred Patient B to us; to Ms. Stevelyn M. Diczok for assistance in manuscript preparation; and to Drs. R. S. Weinger and P. L. Cimo for their clinical insights.

Author Affiliations

From the Hematology-Hemostasis Section, Medical Service, Veterans Administration Medical Center, and Boston University School of Medicine, Boston. Address reprint requests to Dr. Moake at the V.A. Medical Center, Research Rm. 113, 150 S. Huntington Ave., Boston, MA 02130.

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