Volume 34, Issue 1

Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide

N.‐E. ANDÉN

Department of Pharmacology, University of Göteborg, Biochemical Research Laboratories, AB Hässle, Göteborg, and Department of Histology, Karolinska Institutet, Stockholm, Sweden.

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H. CORRODI

Department of Pharmacology, University of Göteborg, Biochemical Research Laboratories, AB Hässle, Göteborg, and Department of Histology, Karolinska Institutet, Stockholm, Sweden.

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K. FUXE

Department of Pharmacology, University of Göteborg, Biochemical Research Laboratories, AB Hässle, Göteborg, and Department of Histology, Karolinska Institutet, Stockholm, Sweden.

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T. HÖKFELT

Department of Pharmacology, University of Göteborg, Biochemical Research Laboratories, AB Hässle, Göteborg, and Department of Histology, Karolinska Institutet, Stockholm, Sweden.

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First published: September 1968
Citations: 226

Abstract

  • 1

    Lysergic acid diethylamide (LSD) and the 5‐hydroxytryptamine (5‐HT) precursor, 5‐hydroxytryptophan produced similar functional effects in rat spinal cord and brain to the 5‐hydroxytryptamine precursor 5‐hydroxytryptophan, which indicates that LSD stimulates central 5‐HT receptors.

  • 2

    By means of combined histochemical and biochemical techniques it was found that LSD reduced the turnover rate of brain and spinal cord 5‐HT, studied after inhibition of the tryptophan hydroxylase by α‐propyldopacet‐amide. The turnover of brain noradrenaline but not dopamine was somewhat accelerated.

  • 3

    The functional and chemical effects by LSD were related to dose and to time. They were not observed after the LSD analogues 2‐bromo‐LSD and methysergide.

  • 4

    The retardation of the 5‐HT turnover by LSD may be due to negative ‐back mechanisms evoked by direct stimulation of the central 5‐HT receptors.