Format

Send to

Choose Destination
Brain Res. 2005 Jan 25;1032(1-2):85-93.

Hemodynamic and respiratory responses to microinjection of ATP into the intermediate and caudal NTS of awake rats.

Author information

1
Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.

Abstract

The nucleus tractus solitarii (NTS) is the site of integration of the peripheral chemoreceptor afferents in the brainstem. Previous studies from our laboratory have shown that microinjection of ATP into the intermediate NTS produced increases in arterial pressure and bradycardia. In the present study, we evaluated the hemodynamic and respiratory responses to microinjection of ATP into the intermediate and caudal commissural NTS. In the same group of rats the responses were compared with cardiorespiratory responses to chemoreflex activation (KCN, i.v.). The data show that microinjection of ATP into the intermediate NTS produced pressor and bradycardic responses similar to those observed in response to chemoreflex activation but apnoea instead of tachypnoea. Microinjection of ATP into caudal commissural NTS produced increase in arterial pressure and tachypnoea similar to the chemoreflex but a minor bradycardia. The data show that microinjection of ATP into different sub-regions of the NTS produces a diverse pattern of hemodynamic and respiratory responses and suggest the involvement of this purine in the neurotransmission of the cardiovascular reflex in the NTS.

PMID:
15680945
DOI:
10.1016/j.brainres.2004.10.048
[Indexed for MEDLINE]

Supplemental Content

Full text links

Loading ...
узнать больше 220km.com

https://adulttorrent.org

start-sport.com.ua/mjachi/gandbol-nye-mjachi