AD Johnson, LR Yanek, MH Chen, N Faraday… - Nature …, 2010 -
Platelet function mediates both beneficial and harmful effects on human health, but few
genes are known to contribute to variability in this process. We tested association of 2.5
million SNPs with platelet aggregation responses to three agonists (ADP, epinephrine and
collagen) in two cohorts of European ancestry (N≤ 2,753 in the Framingham Heart Study,
N≤ 1,238 in the Genetic Study of Atherosclerosis Risk). We identified associations of seven
loci with platelet aggregation near or within GP6 (P= 4.6× 10− 13), PEAR1 (P= 3.4× 10− 12) …