B Voss, JN McLaughlin, M Holinstat, R Zent… - Molecular …, 2007 - ASPET
Thrombin-mediated activation of platelets is critical for hemostasis, but the signaling
pathways responsible for this process are not completely understood. In addition, signaling
within this cascade can also lead to thrombosis. In this study, we have defined a new
signaling pathway for the thrombin receptor protease activated receptor-1 (PAR1) in human
platelets. We show that PAR1 couples to G i/o in human platelets and activates
phosphoinositide-3 kinase (PI3K). PI3K activation regulates platelet integrin αIIbβ3 …