C Soulet, S Gendreau, K Missy, V Benard… - FEBS …, 2001 - Wiley Online Library
In this study, we characterised the mechanisms of Rac GTPase activation in human platelets
stimulated by two physiological agonists, either thrombin, acting through membrane
receptors coupled to heterotrimeric G‐proteins, or collagen which is known to mobilise a
tyrosine kinase‐dependent pathway. Both agonists induced a rapid activation of Rac that
was not significantly affected by the inhibition of integrin αIIbβ3 engagement. Using
pharmacological inhibitors, we found that phospholipase C activation and calcium …