CA Nash, S Severin, BB Dawood… - … of Thrombosis and …, 2010 - Wiley Online Library
Introduction and Background: Adrenaline stimulates biphasic aggregation in plasma through
the Gi‐coupled α2A‐adrenoreceptor. In the present study, we demonstrate that both primary
and secondary wave aggregation induced by adrenaline in plasma is blocked by two
structurally distinct inhibitors of Src family kinases, dasatinib and PD0173952. Methods and
Results: In contrast, primary aggregation is partially inhibited or unaffected in the presence
of inhibitors of cyclo‐oxygenase, phosphoinositide (PI) 3‐kinases, and P2Y1 and P2Y12 …