G Alkhatib, C Combadiere, CC Broder, Y Feng… - …, 1996 - science.sciencemag.org
Human immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on the CD4+
target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves
as a cofactor for T cell line-tropic isolates. The chemokines RANTES, MIP-1α, and MIP-1β,
which suppress infection by macrophage-tropic isolates, selectively inhibited cell fusion
mediated by the corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G
protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells …