GP Anderson, CL Anderson - Blood, 1990 - Am Soc Hematology
We have evaluated the mechanism by which crosslinking human platelet Fc receptor (FcR)
for IgG triggers platelet aggregation and the platelet release reaction. Platelet FcR was
crosslinked by incubating purified human platelets with anti-FcRII monoclonal antibody and
F (ab9) 2 anti-mouse Ig. The resultant [Ca2+] i increase, monitored by Fura-2 and measured
in the absence of extracellular Ca2+, reached a peak of 750+/-50 nmol/L. The effects of
cyclooxygenase inhibitors, aspirin and indomethacin, and a phospholipase A2 inhibitor …