HK Gold, BS Coller, T Yasuda, T Saito, JT Fallon… - Circulation, 1988 - Am Heart Assoc
The effects of bolus injections of recombinant single-chain tissue-type plasminogen activator
(rt-PA) and of F (ab') 2 fragments of a murine monoclonal antibody (7E3) against the human
platelet GPIIb/IIIa receptor [7E3-F (ab') 2] on coronary arterial thrombolysis and reocclusion
was studied in a canine preparation of coronary artery thrombosis superimposed on high-
grade stenosis. Bolus intravenous injections of rt-PA at a dose of 0.45 mg/kg, repeated at 15
min intervals until reperfusion occurred (maximum of four injections) caused reperfusion in …