J Gibbins, J Asselin, R Farndale, M Barnes… - Journal of Biological …, 1996 - ASBMB
Stimulation of platelets by the extracellular matrix protein collagen leads to activation of a
tyrosine kinase-dependent mechanism resulting in secretion and aggregation. Tyrosine
phosphorylation of the tyrosine kinase Syk and phospholipase C γ 2 are early events in
collagen-induced activation. We recently proposed that collagen-signaling in platelets
involves a receptor or a receptor-associated protein containing an immunoreceptor tyrosine-
based activation motif (ITAM) enabling interaction with Syk. In this report we show that …