J Rucker, AL Edinger, M Sharron, M Samson… - Journal of …, 1997 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) requires both CD4 and a coreceptor to infect
cells. Macrophage-tropic (M-tropic) HIV-1 strains utilize the chemokine receptor CCR5 in
conjunction with CD4 to infect cells, while T-cell-tropic (T-tropic) strains generally utilize
CXCR4 as a coreceptor. Some viruses can use both CCR5 and CXCR4 for virus entry (ie,
are dual-tropic), while other chemokine receptors can be used by a subset of virus strains.
Due to the genetic diversity of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and …