JN Thon, CG Peters, KR Machlus, R Aslam, J Rowley… - J Cell Biol, 2012 - jcb.rupress.org
Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which link
the innate and adaptive immune responses during infectious inflammation and
atherosclerotic vascular disease. In this paper, we show that the TLR9 transcript is
specifically up-regulated during pro-PLT production and is distributed to a novel electron-
dense tubular system-related compartment we have named the T granule. TLR9 colocalizes
with protein disulfide isomerase and is associated with either VAMP 7 or VAMP 8, which …