K Droebner, E Haasbach, C Fuchs, AO Weinzierl… - Vaccine, 2008 - Elsevier
Abstract A H5N2 low pathogenic avian influenza virus (LPAIV) was isolated from a natural
reservoir in Bavaria during a routine screen and was used as a vaccine strain to scrutinize
the immune response involved in cross-protection after challenge infection with a H5N1
highly pathogenic avian influenza virus (HPAIV). The challenge virus was also isolated from
a natural reservoir in Bavaria. Wild type, antibody deficient (μMT), CD4−/− and CD8−/− mice
were infected with the apathogenic H5N2 vaccine strain and challenge infection with a 100 …