K Krauel, C Pötschke, C Weber, W Kessler, B Fürll… - Blood, 2011 - Am Soc Hematology
A clinically important adverse drug reaction, heparin-induced thrombocytopenia (HIT), is
induced by antibodies specific for complexes of the chemokine platelet factor 4 (PF4) and
the polyanion heparin. Even heparin-naive patients can generate anti-PF4/heparin IgG as
early as day 4 of heparin treatment, suggesting preimmunization by antigens mimicking
PF4/heparin complexes. These antibodies probably result from bacterial infections, as (1)
PF4 bound charge-dependently to various bacteria,(2) human heparin-induced anti …