KMS O'Connell, R Loftus… - Proceedings of the …, 2010 - National Acad Sciences
The Kv2. 1 K+ channel is highly expressed throughout the brain, where it regulates
excitability during periods of high-frequency stimulation. Kv2. 1 is unique among Kv
channels in that it targets to large surface clusters on the neuronal soma and proximal
dendrites. These clusters also form in transfected HEK cells. Following excessive excitatory
stimulation, Kv2. 1 declusters with an accompanying 20-to 30-mV hyperpolarizing shift in the
activation threshold. Although most Kv2. 1 channels are clustered, there is a pool of Kv2. 1 …