KJ Kao, DJ Cook, JC Scornik - Blood, 1986 - Am Soc Hematology
Class I molecules of human major histocompatibility complex (HLA) are the most important
antigenic system in determining the survival of transfused platelets in alloimmunized
patients. Platelets with reduced expression of a specific type of HLA antigen may escape
specific anti-HLA antibody-mediated destruction. By using 125I-labeled Fab fragments of
W6/32 anti-HLA monoclonal antibody and competitive protein binding assays, we measured
the range of total HLA concentrations on platelets. In 12 individuals examined, the mean …