MD Kazatchkine, CR Lambre, N Kieffer… - The Journal of …, 1984 - Am Soc Clin Investig
Influenza A virus-treated human platelets were lyzed in autologous serum. Lysis required
the presence of antibody and occurred predominantly through activation of the classical
complement pathway. Binding of the virus followed by its elution at 37 degrees C resulted in
a dose-dependent desialation of the cells with a maximal release of 45% of total platelet
sialic acid. In contrast, platelets that had been treated with Vibrio cholerae neuraminidase
and from which 55% of total sialic acid had been removed were not lyzed in autologous …