MD De Jong, CP Simmons, TT Thanh, VM Hien… - Nature medicine, 2006 -
Abstract Avian influenza A (H5N1) viruses cause severe disease in humans 1, 2, but the
basis for their virulence remains unclear. In vitro and animal studies indicate that high and
disseminated viral replication is important for disease pathogenesis 3, 4, 5. Laboratory
experiments suggest that virus-induced cytokine dysregulation may contribute to disease
severity 6, 7, 8, 9. To assess the relevance of these findings for human disease, we
performed virological and immunological studies in 18 individuals with H5N1 and 8 …