R Aslam, ER Speck, M Kim, AR Crow, KWA Bang… - Blood, 2006 - Am Soc Hematology
Toll-like receptors (TLRs) play a critical role in stimulating innate immunity by recognizing
pathogen-associated molecular patterns (PAMPs) on invading microorganisms. Platelets
also play a role in innate immunity, and we studied whether they express TLR. Results show
that human and murine platelets variably expressed TLR2, TLR4, and TLR9 by flow
cytometry and Western blotting. TLR4 expression was confirmed by demonstrating murine
platelet binding to lipopolysaccharide (LPS). Thrombin activation of the platelets significantly …