R Horuk, J Hesselgesser, Y Zhou, D Faulds… - Journal of Biological …, 1998 - ASBMB
Using a chemokine receptor model based on known receptor sequences, we identified
several members of the seven transmembrane domain G-protein superfamily as potential
chemokine receptors. The orphan receptor ChemR1, which has recently been shown to be a
receptor for the CC chemokine I-309, scored very high in our model. We have confirmed that
I-309, but not a number of other chemokines, can induce a transient Ca 2+ flux in cells
expressing CCR8. In addition, the human erythroleukemic cell line K562 responded …