S Karpatkin, E Pearlstein - Annals of internal medicine, 1981 - Am Coll Physicians
Platelets may have a role in the development of animal tumor metastases. Ultrastructural
studies in vivo have shown arrested tumor emboli surrounded by platelets. Several tumor
cell lines induce thrombocytopenia in vivo. Certain tumor cells aggregate platelets in vitro.
Correlations exist between the ability of some tumor cells to aggregate platelets in vitro and
their metastatic potential in vivo. Antiplatelet agents have impaired or altered the spread of
certain tumor metastases. It is suggested that platelets have a role in the sequestration …