S Lee, JGT Wurtzel, SS Singhal, S Awasthi… - Cancer research, 2012 - AACR
RalBP1/RLIP76 is a widely expressed multifunctional protein that binds the Ral and R-Ras
small GTPases. In the mouse, RLIP76 is nonessential but its depletion or blockade promotes
tumorigenesis and heightens the sensitivity of normal and tumor cells to radiation and
cytotoxic drugs. However, its pathobiologic functions, which support tumorigenesis, are not
well understood. Here, we show that RLIP76 is required for angiogenesis and for efficient
neovascularization of primary solid tumors. Tumor growth from implanted melanoma or …