SW Kerrigan, I Douglas, A Wray, J Heath, MF Byrne… - Blood, 2002 - Am Soc Hematology
Numerous studies have implicated bacteria in cardiovascular disease, but there is a paucity
of information on the mechanism involved. In this study we show how the common oral
bacteriumStreptococcus sanguis can directly interact with platelets, resulting in activation
and aggregate formation. Platelet aggregation was dependent on glycoprotein IIb/IIIa
(GPIIb/IIIa) and thromboxane. Platelets could also directly bind to S sanguis, but this
interaction was not inhibited by GPIIb/IIIa antagonists. Antibodies to GPIb could inhibit both …