V Henn, S Steinbach, K Büchner, P Presek… - Blood, 2001 - Am Soc Hematology
Recently, we have demonstrated that human platelets carry preformed CD40 ligand
(CD154) molecules, which rapidly appear on the platelet surface following stimulation by
thrombin. Once on the surface, platelet CD154 induces an inflammatory reaction of CD40-
bearing endothelial cells. This study shows that strong platelet agonists other than thrombin
also lead to the expression of CD154 on the platelet surface. At the same time, several lines
of evidence are presented that together indicate that thrombotic events in the vasculature …