XR Bustelo - Molecular and cellular biology, 2000 - Am Soc Microbiol
The GTP hydrolases of the Rho/Rac family participate in the generation of coordinated
cellular responses to extracellular stimuli (52, 153). Their actions are essential to promote
the formation of cytoskeletal structures that contribute to changes in cell shape and motility,
the activation of lipid and protein kinase cascades, and the induction of patterns of gene
expression required for both developmental and proliferative decisions (52, 153). The
functions of these proteins are also associated with a number of human disorders. Thus …