Y Takeuchi, M Akutsu, K Murayama, N Shimizu… - Journal of …, 1991 - Am Soc Microbiol
We have isolated a variant of human immunodeficiency virus type 1 (HIV-1) which is highly
infectious to fibroblastlike cells (BT cells) derived from human brain as well as CD4-positive
T cells. This variant HIV-1, named HIV [GUN-1V], was obtained by infecting BT cells with a
prototype HIV-1 isolate, named HIV [GUN-1WT], which is highly infectious to T cells but
barely infectious to BT cells. HIV [GUN-1V] infects BT cells productively and this infection
appeared to be mediated by CD4. To elucidate the viral gene responsible for the host range …