RF Hwang, T Moore, T Arumugam, V Ramachandran… - Cancer research, 2008 - AACR
Pancreatic adenocarcinoma is characterized by a dense background of tumor associated
stroma originating from abundant pancreatic stellate cells. The aim of this study was to
determine the effect of human pancreatic stellate cells (HPSC) on pancreatic tumor
progression. HPSCs were isolated from resected pancreatic adenocarcinoma samples and
immortalized with telomerase and SV40 large T antigen. Effects of HPSC conditioned
medium (HPSC-CM) on in vitro proliferation, migration, invasion, soft-agar colony formation …
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