JS Smith, CA Iannotti, P Dargis… - Journal of …, 2001 - Soc Neuroscience
The KCNQ family of K+ channels has been implicated in several cardiac and neurological
disease pathologies. KCNQ2 (Q2) is a brain-derived gene, which in association with KCNQ3
(Q3) has been shown to provide a molecular basis for the neuronal M current. We have
cloned a long (Q2L) and a short (Q2S) splice variant of the human KCNQ2 gene; these
variants differ in their C-terminal tail. Northern blot analysis reveals that Q2L is preferentially
expressed in differentiated neurons, whereas the Q2S transcript is prominent in fetal brain …
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