Профили пользователей по запросу "D. Stryke"

Doug Stryke

Software Architect/Developer, University of California, San Francisco
Подтвержден адрес электронной почты в домене ucsf.edu
Цитируется: 3971

…, M Kawamoto, SJ Johns, D Stryke… - Pharmacogenetics …, 2003 - journals.lww.com
Objectives There is increasing evidence that polymorphism of the ABCB1 (MDR1) gene
contributes to interindividual variability in bioavailability and tissue distribution of P-
glycoprotein substrates. The aim of the present study was to (1) identify and describe novel …

…, LM Mangravite, CC Huang, D Stryke… - Proceedings of the …, 2003 - National Acad Sciences
The organic cation transporter, OCT1, is a major hepatic transporter that mediates the
uptake of many organic cations from the blood into the liver where the compounds may be
metabolized or secreted into the bile. Because OCT1 interacts with a variety of structurally …

D Stryke, M Kawamoto, CC Huang… - Nucleic acids …, 2003 - academic.oup.com
The BayGenomics gene-trap resource (http://baygenomics. ucsf. edu) provides researchers
with access to thousands of mouse embryonic stem (ES) cell lines harboring characterized
insertional mutations in both known and novel genes. Each cell line contains an insertional …

…, M de La Cruz, SJ Johns, D Stryke… - Proceedings of the …, 2003 - National Acad Sciences
Membrane transporters maintain cellular and organismal homeostasis by importing nutrients
and exporting toxic compounds. Transporters also play a crucial role in drug response,
serving as drug targets and setting drug levels. As part of a pharmacogenetics project, we …

…, G Yu, S Somasekar, S Federman, D Stryke… - The Lancet Infectious …, 2015 - Elsevier
Background Enterovirus D68 was implicated in a widespread outbreak of severe respiratory
illness across the USA in 2014 and has also been reported sporadically in patients with
acute flaccid myelitis. We aimed to investigate the association between enterovirus D68 …


…, G Yu, P Mbala, V Bres, D Stryke… - Genome …, 2015 - genomemedicine.biomedcentral …
We report unbiased metagenomic detection of chikungunya virus (CHIKV), Ebola virus
(EBOV), and hepatitis C virus (HCV) from four human blood samples by MinION nanopore
sequencing coupled to a newly developed, web-based pipeline for real-time bioinformatics …

…, M Kawamoto, SJ Johns, D Stryke… - Pharmacogenetics …, 2002 - journals.lww.com
The completion of the Human Genome Project and the development of high-throughput
polymorphism identification methods have allowed researchers to carry out full genetic
analyses of many clinically relevant genes. However, few studies have combined genetic …

…, TR Taylor, CM Brett, CC Huang, D Stryke… - … of Pharmacology and …, 2006 - ASPET
Methotrexate (MTX) is used in patients with malignant and autoimmune diseases. This drug
is primarily excreted unchanged in the urine, and its net excretion occurs via active secretory
and reabsorptive processes. We characterized the interaction of MTX with human organic …


…, A Schlessinger, SS More, D Stryke… - Pharmacogenetics …, 2010 - ncbi.nlm.nih.gov
Objectives The goals of this study were to determine the role of OCT3 in the pharmacologic
action of metformin and to identify and functionally characterize genetic variants of OCT3
with respect to the uptake of metformin and monoamines. Methods For the pharmacologic …

…, JH Morris, S Ojha, AM Schnoes, D Stryke… - Nucleic acids …, 2013 - academic.oup.com
Abstract The Structure–Function Linkage Database (SFLD, http://sfld. rbvi. ucsf. edu/) is a
manually curated classification resource describing structure–function relationships for
functionally diverse enzyme superfamilies. Members of such superfamilies are diverse in …