…, V Sundvold, M Saxena, FO Levy… - Journal of …, 2001 - jem.rupress.org
In T cells, cAMP-dependent protein kinase (PKA) type I colocalizes with the T cell receptor–
CD3 complex (TCR/CD3) and inhibits T cell function via a previously unknown proximal
target. Here we examine the mechanism for this PKA-mediated immunomodulation. cAMP …

AJ Kaumann, FO Levy - Pharmacology & therapeutics, 2006 - Elsevier
The human cardiovascular system is exposed to plasma 5-hydroxytryptamine (5-HT,
serotonin), usually released from platelets. 5-HT can produce harmful acute and chronic
effects. The acute cardiac effects of 5-HT consist of tachycardia (preceded on occasion by a …

T Ringerike, FD Blystad, FO Levy… - Journal of cell …, 2002 - jcs.biologists.org
We have investigated the localization and function of the epidermal growth factor receptor
(EGFR) in normal cells, in cholesterol-depleted cells and in cholesterol enriched cells. Using
immunoelectron microscopy we find that the EGFR is randomly distributed at the plasma …

…, R Solberg, HK Knutsen, FO Levy… - Advances in second …, 1997 - europepmc.org
A large number of hormones, neurotransmitters, and other signaling substances that bind to
G-protein-coupled cell-surface receptors have their signals converge at one sole second
messenger, cAMP. The question of how specificity can be maintained in a signal …

…, KA Krobert, T Brattelid, AJ Kaumann, FO Levy - Naunyn-Schmiedeberg's …, 2001 - Springer
5-Hydroxytryptamine (5-HT) increases human heart rate and atrial contractile force and
hastens atrial relaxation through 5-HT 4 receptors. Moreover, 5-HT may be arrhythmogenic
and give rise to atrial fibrillation. It is not clear which splice variant (s) of the 5-HT 4 receptor …

FO Levy, X Zhu, AJ Kaumann… - Proceedings of the …, 1993 - National Acad Sciences
We investigated the relative activity at which fully occupied human beta 1-and beta 2-
adrenergic receptors (beta 1AR and beta 2AR) activate the stimulatory G protein
(Gs)/adenylyl cyclase (AC) system in isolated membranes. The receptors were cloned and …

FO Levy, O Øyen, M Sandberg, K Taskén… - Molecular …, 1988 - academic.oup.com
In this study, we report the isolation and characterization of a full-length cDNA clone for the
hormone-inducible regulatory subunit RIIβ (formerly called RII51) of type II cAMP-dependent
protein kinase from a human testis cDNA library. The cloned cDNA demonstrated tissue …

JH Norum, K Hart, FO Levy - Journal of Biological Chemistry, 2003 - ASBMB
Receptor tyrosine kinases activate mitogen-activated protein (MAP) kinases through Ras,
Raf-1, and MEK. Receptor tyrosine kinases can be transactivated by G protein-coupled
receptors coupling to G i and G q. The human G protein-coupled serotonin receptors 5-HT 4 …

KA Krobert, FO Levy - British journal of pharmacology, 2002 - Wiley Online Library
Using membranes from stably or transiently transfected HEK293 cells cultured in 5‐HT‐free
medium and expressing the recombinant human 5‐HT7 receptor splice variants (h5‐HT7
(a), h5‐HT7 (b) and h5‐HT7 (d)), we compared their abilities to constitutively activate …

FO Levy, T Gudermann, E Perez-Reyes… - Journal of Biological …, 1992 - ASBMB
We report the molecular cloning of a fragment of human genomic DNA called S12,
containing an open reading frame of 1170 nucleotides, which encodes a receptor for
serotonin of 390 amino acids. The receptor function of the S12 protein was demonstrated by …