JM Summy, GE Gallick - Cancer and metastasis reviews, 2003 - Springer
The Src family of non-receptor protein tyrosine kinases plays critical roles in a variety of
cellular signal transduction pathways, regulating such diverse processes as cell division,
motility, adhesion, angiogenesis, and survival. Constitutively activated variants of Src family …

…, H Wang, L Marquis, JL Abbruzzese, GE Gallick… - Cancer research, 2009 - AACR
A better understanding of drug resistance mechanisms is required to improve outcomes in
patients with pancreatic cancer. Here, we characterized patterns of sensitivity and resistance
to three conventional chemotherapeutic agents with divergent mechanisms of action …

…, A Ahmad, AS Azmi, S Ali, JL Abbruzzese, GE Gallick… - Cancer research, 2009 - AACR
Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most
difficult human malignancies to treat due, in part, to de novo and acquired chemoresistance
and radioresistance. Gemcitabine alone or in combination with other conventional …

…, MS Roh, SA Curley, GE Gallick - The Journal of clinical …, 1993 - Am Soc Clin Investig
Activation of the tyrosine kinase of the c-src gene product, pp60c-src, has been shown to
occur in nearly every primary colorectal carcinoma, and is found as early as in polyps of high
malignant potential. However, no studies have addressed potential pp60c-src changes …

…, J Zhang, SI Park, NU Parikh, GE Gallick - Annals of surgical …, 2007 - Springer
Background Pancreatic cancer is an exceptionally lethal disease with an annual mortality
nearly equivalent to its annual incidence. This dismal rate of survival is due to several factors
including late presentation with locally advanced, unresectable tumors, early metastatic …


…, GL Semenza, DB Evans, SS Watowich, GE Gallick - Oncogene, 2005 -
Hypoxia stimulates a number of pathways critical to cancer cell survival, including the
activation of vascular endothelial growth factor (VEGF) transcription. In normal fibroblasts,
hypoxia-induced activation of the protein tyrosine kinase, Src, is required for VEGF …

…, BW Ahn, W Liu, CD Bucana, GE Gallick… - British journal of …, 2001 -
Catechins are key components of teas that have antiproliferative properties. We investigated
the effects of green tea catechins on intracellular signalling and VEGF induction in vitro in
serum-deprived HT29 human colon cancer cells and in vivo on the growth of HT29 cells in …

JM Summy, GE Gallick - Clinical Cancer Research, 2006 - AACR
Background The non–receptor protein tyrosine, Src, is a 60-kDa protein that is the
archetypal member of a nine-gene family, including Src, Yes, Fyn, Lyn, Lck, Hck, Fgr, Blk,
and Yrk, that plays a critical role in regulation of proliferation, differentiation, migration …

…, NU Parikh, CD Bucana, GE Gallick - Journal of Biological …, 1998 - ASBMB
Vascular endothelial growth factor (VEGF) is implicated in the angiogenesis of human colon
cancer. Recent evidence suggests that factors that regulate VEGF expression may partially
depend on c-src-mediated signal transduction pathways. The tyrosine kinase activity of Src …

…, MM Heiss, EK Abdalla, SA Curley, GE Gallick - Cancer, 2002 - Wiley Online Library
BACKGROUND The specific activity of the non‐receptor protein tyrosine kinase, Src, is
increased in the majority of colon and rectal adenocarcinomas compared to normal mucosa.
However, the prognostic significance of this difference is unknown. The objective of the …