Physical and chemical strategies for therapeutic delivery by using polymeric nanoparticles

JM Morachis, EA Mahmoud, A Almutairi - Pharmacological reviews, 2012 - ASPET
A significant challenge that most therapeutic agents face is their inability to be delivered
effectively. Nanotechnology offers a solution to allow for safe, high-dose, specific delivery of
pharmaceuticals to the target tissue. Nanoparticles composed of biodegradable polymers …

…, EA Mahmoud, G Kim, JM Morachis… - Acs Nano, 2010 - ACS Publications
Logic gate nanoparticles, where two chemical transformations take place one after the other,
were successfully formulated from a newly synthesized random co-polymer. This polymer,
poly ([2, 2′-(propane-2, 2-diylbis (oxy)) bis (ethane-2, 1-diyl) diacrylate]-co-[hexane-1, 6 …

…, J Sankaranarayanan, JM Morachis… - Bioconjugate …, 2011 - ACS Publications
Oxidative stress and reduced pH are important stimuli targets for intracellular delivery and
for delivery to diseased tissue. However, there is a dearth of materials able to deliver
bioactive agents selectively under these conditions. We employed our recently developed …

…, CL McFearin, M Sermsakdi, JM Morachis… - …, 2011 - ACS Publications
Near infrared (NIR) irradiation can penetrate up to 10 cm deep into tissues and be remotely
applied with high spatial and temporal precision. Despite its potential for various medical
and biological applications, there is a dearth of biomaterials that are responsive at this …

JM Morachis, CM Murawsky… - Genes & …, 2010 - genesdev.cshlp.org
Abstract p53 target promoters are structurally diverse and display pronounced differences in
RNA polymerase II (RNAP II) occupancy even in unstressed cells, with higher levels
observed on cell cycle arrest genes (p21) compared with apoptotic genes (Fas/APO1). This …

JH Dao, RJM Kurzeja, JM Morachis, H Veith… - Analytical …, 2009 - Elsevier
The human hypoxia-inducible factor prolyl hydroxylases 1, 2, and 3 (HIF–PHD1,-2, and-3)
are thought to act as proximal sensors of cellular hypoxia by virtue of their mechanism-
based dependence on molecular oxygen. These 2-oxoglutarate (2-OG) and non-heme iron …

JM Morachis, EA Mahmoud… - Journal of drug …, 2012 - hindawi.com
Effective gene delivery tools offer the possibility of addressing multiple diseases; current
strategies rely on viruses or polyplexes. Encapsulation of DNA within nanoparticles is an
attractive alternative method for gene delivery. We investigated the use of our recently …

…, J Sankaranarayanan, JM Morachis… - Integrative …, 2012 - academic.oup.com
Particle-based delivery of encapsulated antigens has great potential for improving vaccine
constructs. In this study, we show that antigen-loaded, pH-sensitive hydrogel microparticles are
taken up and presented by bone marrow-derived dendritic cells (BMDCs) in vitro and are taken …

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JM Morachis, R Huang, BM Emerson - Oncotarget, 2011 - ncbi.nlm.nih.gov
Our current understanding of eukaryotic transcription has greatly benefited from use of small
molecule inhibitors that have delineated multiple regulatory steps in site-specific initiation
and elongation of RNA synthesis by multiple forms of RNA polymerase (RNAP). This class of …

NP Gomes, JM Espinosa - Genes & development, 2010 - genesdev.cshlp.org
… Mol Cell Biol 27:1309–1320. Abstract/FREE Full Text. ↵: Morachis JM,; Murawsky CM,;
Emerson BM. (2010) Regulation of the p53 transcriptional response by structurally diverse
core promoters. Genes & Dev doi:10.1101/gad.1856710, (this issue) …