LL Isom, KS De Jongh, DE Patton, BF Reber… - …, 1992 - science.sciencemag.org
Voltage-sensitive sodium channels are responsible for the initiation and propagation of the
action potential and therefore are important for neuronal excitability. Complementary DNA
clones encoding the beta 1 subunit of the rat brain sodium channel were isolated by a …

LL Isom, KS De Jongh, WA Catterall - Neuron, 1994 - Elsevier
The voltage-gated Na+, Ca*+, and K+ channels are responsible for the generation of action
potentials in neurons and other excitable cells. These channels are also involved in cellular
regulation in nonexcitablecell types. Voltage-gated ion channels all contain principal …

LL Isom, DS Ragsdale, KS De Jongh, RE Westenbroek… - Cell, 1995 - Elsevier
Voltage-gated sodium channels in brain neurons are complexes of a pore-forming a subunit
with smaller β1 and β2 subunits. cDNA cloning and sequencing showed that the β2 subunit
is a 186 residue glycoprotein with an extracellular NH 2-terminal domain containing an …

LL Isom - The Neuroscientist, 2001 - journals.sagepub.com
Voltage-gated sodium channels are glycoprotein complexes responsible for initiation and
propagation of action potentials in excitable cells such as central and peripheral neurons,
cardiac and skeletal muscle myocytes, and neuroendocrine cells. Mammalian sodium …

…, K Kazen-Gillespie, M Hortsch, LL Isom - Journal of Biological …, 2000 - ASBMB
Sodium channels isolated from mammalian brain are composed of α, β1, and β2 subunits.
The auxiliary β subunits do not form the ion conducting pore, yet play important roles in
channel modulation and plasma membrane expression. β1 and β2 are transmembrane …


MR Kaplan, MH Cho, EM Ullian, LL Isom, SR Levinson… - Neuron, 2001 - Elsevier
Na v 1.6 is the main sodium channel isoform at adult nodes of Ranvier. Here, we show that
Na v 1.2 and its β2 subunit, but not Na v 1.6 or β1, are clustered in developing central
nervous system nodes and that clustering of Na v 1.2 and Na v 1.6 is differentially controlled …

…, GA Patino, SM Taffet, LL Isom… - Circulation …, 2009 - Am Heart Assoc
Rationale: Plakophilin-2 (PKP2) is an essential component of the cardiac desmosome.
Recent data show that it interacts with other molecules of the intercalated disc. Separate
studies show preferential localization of the voltage-gated sodium channel (NaV1. 5) to this …

…, P Shrager, WA Catterall, LL Isom - Journal of …, 2004 - Soc Neuroscience
Sodium channel β1 subunits modulate α subunit gating and cell surface expression and
participate in cell adhesive interactions in vitro. β1 (-/-) mice appear ataxic and display
spontaneous generalized seizures. In the optic nerve, the fastest components of the …

S Hong, TJ Morrow, PE Paulson, LL Isom… - Journal of Biological …, 2004 - ASBMB
Diabetic neuropathy is a common form of peripheral neuropathy, yet the mechanisms
responsible for pain in this disease are poorly understood. Alterations in the expression and
function of voltage-gated tetrodotoxin-resistant (TTX-R) sodium channels have been …

…, LN Mattei, PE Braun, M Schachner, LL Isom - Journal of Biological …, 1999 - ASBMB
Voltage-gated sodium channels isolated from mammalian brain are composed of α, β1, and
β2 subunits. The α subunit forms the ion conducting pore of the channel, whereas the β1
and β2 subunits modulate channel function, as well as channel plasma membrane …