A Aspelund, MR Robciuc, S Karaman… - Circulation …, 2016 - Am Heart Assoc
The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a
unidirectional transit pathway from the extracellular space to the venous system. It actively …

MR Robciuc, M Maranghi, A Lahikainen… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Angiopoietin-like 3 (Angptl3) is a regulator of lipoprotein metabolism at least by
inhibiting lipoprotein lipase activity. Loss-of-function mutations in ANGPTL3 cause familial
combined hypolipidemia through an unknown mechanism. Approach and Results—We …

R Kivelä, M Bry, MR Robciuc, M Räsänen… - EMBO molecular …, 2014 - embopress.org
Angiogenic growth factors have recently been linked to tissue metabolism. We have used
genetic gain‐and loss‐of function models to elucidate the effects and mechanisms of action
of vascular endothelial growth factor‐B (VEGF‐B) in the heart. A cardiomyocyte‐specific …

MR Robciuc, E Tahvanainen, M Jauhiainen… - Journal of lipid …, 2010 - ASBMB
We have developed and validated quantitative ELISAs for human angiopoietin-like
(ANGPTL) 3 and 4 and correlated their serum levels with parameters of lipid and
carbohydrate metabolism. For this study, we used a random subsample of the Health 2000 …


MR Robciuc, R Kivelä, IM Williams, JF de Boer… - Cell metabolism, 2016 - Elsevier
Impaired angiogenesis has been implicated in adipose tissue dysfunction and the
development of obesity and associated metabolic disorders. Here, we report the unexpected
finding that vascular endothelial growth factor B (VEGFB) gene transduction into mice …

…, G Zarkada, W Zheng, MR Robciuc… - EMBO molecular …, 2015 - embopress.org
Vascular endothelial growth factor C (VEGF‐C) binding to its tyrosine kinase receptor
VEGFR‐3 drives lymphatic vessel growth during development and in pathological
processes. Although the VEGF‐C/VEGFR‐3 pathway provides a target for treatment of …

AV Gafencu, MR Robciuc, E Fuior, VI Zannis… - Journal of Biological …, 2007 - ASBMB
The atheroprotective role of apolipoprotein E (apoE) is well established. During
inflammation, expression of apoE in macrophages is reduced leading to enhanced
atheromatous plaque development. In the present study, we investigated the signaling …

MR Robciuc, J Naukkarinen, A Ortega-Alonso… - Journal of lipid …, 2011 - ASBMB
Animal studies have suggested that angiopoietin-like 4 (Angptl4) regulates adiposity
through central and peripheral mechanisms. The aim of this study was to investigate
whether serum concentration and adipose tissue expression of Angptl4 are associated with …

I Minicocci, A Montali, MR Robciuc… - The Journal of …, 2012 - academic.oup.com
Context: Familial combined hypolipidemia causes a global reduction of plasma lipoproteins.
Its clinical correlates and metabolic implications have not been well defined. Objective: The
objective of the study was to investigate the genetic, clinical, and metabolic characteristics of …

MC Smart-Halajko, MR Robciuc… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—To investigate the relationship between angiopoietin-like protein 4 (Angptl4)
levels, coronary heart disease (CHD) biomarkers, and ANGPTL4 variants. Methods and
Results—Plasma Angptl4 was quantified in 666 subjects of the Northwick Park Heart Study II …