…, M Tsai, K Asai, M Maeda-Yamamoto… - Proceedings of the …, 2003 - National Acad Sciences
We demonstrate that binding of different IgE molecules (IgEs) to their receptor, FcεRI,
induces a spectrum of activation events in the absence of a specific antigen and provide
evidence that such activation reflects aggregation of FcεRI. Highly cytokinergic IgEs can …

…, K Yoshino, M Maeda-Yamamoto - Journal of agricultural …, 1999 - ACS Publications
Two catechin derivatives (C-1 and C-2) with potent antiallergic activity were isolated from
Taiwanese oolong tea by HPLC techniques. From NMR and FAB-MS analyses, the
structures of C-1 and C-2 were elucidated as (−)-epigallocatechin 3-O-(3-O-methyl) gallate …

…, WN Khan, M Maeda-Yamamoto… - Journal of …, 1998 - jem.rupress.org
We investigated the role of Bruton9s tyrosine kinase (Btk) in FcεRI-dependent activation of
mouse mast cells, using xid and btk null mutant mice. Unlike B cell development, mast cell
development is apparently normal in these btk mutant mice. However, mast cells derived …

…, H Nishimoto, J Kitaura, M Maeda-Yamamoto… - Journal of Biological …, 2004 - ASBMB
Abstract Akt (= protein kinase B), a subfamily of the AGC serine/threonine kinases, plays
critical roles in survival, proliferation, glucose metabolism, and other cellular functions. Akt
activation requires the recruitment of the enzyme to the plasma membrane by interacting …

M Maeda-Yamamoto, H Kawahara… - Journal of agricultural …, 1999 - ACS Publications
The effects of tea polyphenols on the invasion of highly metastatic human fibrosarcoma
HT1080 cells through a monolayer of human umbilical vein endothelial cells (HUVECs) and
the accompanying basal membrane were investigated. Among the tea polyphenols tested …

…, SE Hartman, M Maeda-Yamamoto… - The Journal of …, 2000 - Am Assoc Immnol
Protein-tyrosine kinases play crucial roles in mast cell activation through the high-affinity IgE
receptor (FcεRI). In this study, we have made the following observations on growth
properties and FcεRI-mediated signal transduction of primary cultured mast cells from Btk …

M Maeda-Yamamoto, N Inagaki, J Kitaura… - The Journal of …, 2004 - Am Assoc Immnol
Tea contains a variety of bioactive compounds. In this study, we show that two O-methylated
catechins,(-)-epigallocatechin-3-O-(3-O-methyl) gallate and (-)-epigallocatechin-3-O-(4-O-
methyl) gallate, inhibit in vivo mast cell-dependent allergic reactions more potently than their …

J Kitaura, K Asai, M Maeda-Yamamoto… - Journal of …, 2000 - jem.rupress.org
Cross-linking of FcεRI induces the activation of three protein tyrosine kinases, Lyn, Syk, and
Bruton9s tyrosine kinase (Btk), leading to the secretion of a panel of proinflammatory
mediators from mast cells. This study showed phosphorylation at Ser-473 and enzymatic …

…, M Suzuki, M Degawa, T Miyase, M Maeda-Yamamoto - Analyst, 2001 - pubs.rsc.org
A high-performance liquid chromatographic method with electrochemical detection was
developed for the determination of twelve tea catechins including four major catechins:
epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin …

…, M Maeda-Yamamoto, T Miyase, M Sano - Journal of agricultural …, 2000 - ACS Publications
The inhibitory effects of tea catechins, the O-methylated derivatives of (−)-epigallocatechin-3-
O-gallate (EGCG), and the polyphenol extracts from tea leaves (Camellia sinensis L.) on
oxazolone-induced type IV allergy in male ICR mice were investigated. Four major tea …