…, NF Dawson, C Zhao, C Bond, RJ Summers… - Journal of Biological …, 2002 - ASBMB
We have identified a novel human relaxin gene, designated H3 relaxin, and an equivalent
relaxin gene in the mouse from the Celera Genomics data base. Both genes encode a
putative prohormone sequence incorporating the classic two-chain, three cysteine-bonded …

MJ Christie, RJ Summers, JA Stephenson, CJ Cook… - Neuroscience, 1987 - Elsevier
Afferents to the nucleus accumbens septi utilizing glutamate or aspartate have been
investigated in the rat by autoradiography following injection and retrograde transport of d [3
H] aspartate. Parallel experiments with the intra-accumbal injection of [3 H] GABA were …

…, GE Callander, M Kocan, RJ Summers - Physiological …, 2013 - physiology.org
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous
system, as a vasodilator and cardiac stimulant in the cardiovascular system, and as an …

International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides

…, R Ivell, BM Sanborn, OD Sherwood, RJ Summers - Pharmacological …, 2006 - ASPET
Although the hormone relaxin was discovered 80 years ago, only in the past 5 years have
the receptors for relaxin and three other receptors that respond to related peptides been
identified with all four receptors being G-protein-coupled receptors. In this review it is …

…, PF Kohler, A Saxon, RJ Summers… - Archives of internal …, 1992 - jamanetwork.com
Background.—A history (or lack thereof) of penicillin allergy is known to be unreliable in
predicting reactions on subsequent administration of the drug. This study tests the
usefulness of four penicillin allergen skin tests in the prediction of IgE-mediated reactions …


PD Hrdina, B Foy, A Hepner, RJ Summers - Journal of Pharmacology and …, 1990 - Citeseer
Binding of two different antidepressant drugs,[3H] paroxetine and [3H] imipramine in 30 rat
brain regions was visualized, corn-pared and quantified by means of autoradiography and
densitom-etry. Specific binding of [3H] paroxetine to coronal sections of diencephalon …

…, CP Bond, MD Burton, LJ Parry, RJ Summers… - The FASEB …, 2003 - fasebj.org
SPECIFIC AIMS The peptide hormone relaxin is known for its actions on the female
reproductive system and its potential ability to inhibit short-term collagen production from
tissues and cell culture models. In the present study, the long-term effects of relaxin …

ME Gibbs, RJ Summers - Progress in neurobiology, 2002 - Elsevier
Noradrenaline release in areas within the forebrain occurs following activation of
noradrenergic cells in the locus coeruleus (LoC). Release of noradrenaline by
attentional/arousal/vigilance factors appears to be essential for learning and is responsible …

…, CS Samuel, AM Dart, RJ Summers - Nature Reviews …, 2010 - nature.com
Although substantial advances have been achieved in recent decades in the clinical
management of heart diseases, new therapies that provide better or additional efficacy with
minimal adverse effects are urgently required. Evidence that has accumulated since the …

…, R Sridhar, OL Woodman, LJ Miller, RJ Summers… - Molecular …, 2010 - ASPET
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a
major therapeutic target for treatment of diabetes. However, GLP-1 receptor function is
complex, with multiple endogenous peptides that can interact with the receptor, including full …