…, M Kawasaki, Y Matsuno, T Yamada, S Hirohashi… - Cancer, 1995 - Wiley Online Library
Background. Although there are many reported prognostic indicators for pulmonary
adenocarcinoma, the clinicopathologic characteristics and prognostic factors of early stage
adenocarcinoma have not been evaluated fully, except for several studies of nonmucinous …

…, J Yamamoto, K Shimada, M Sakamoto, S Hirohashi… - The Lancet, 2000 - Elsevier
Background Postsurgical recurrence of hepatocellular carcinoma (HCC) is frequent and
fatal. Adoptive immunotherapy is active against HCC. We assessed whether postoperative
immunotherapy could lower the frequency of recurrence. Methods Between 1992 and 1995 …

S Hirohashi - The American journal of pathology, 1998 - Elsevier
It has long been known that cell-cell adhesiveness is generally reduced in human cancers.
Tumor cells are dissociated throughout the entire tumor masses of diffuse-type cancers,
whereas those of solid tumors with high metastatic potentials are often focally dissociated or …

…, T Sugimura, S Hirohashi - Proceedings of the …, 1995 - National Acad Sciences
E-Cadherin, a cell adhesion molecule, which plays a key role in maintaining the epithelial
phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence
from in vitro experiments and clinical observations. In an attempt to clarify the mechanism …

Y Shimoyama, S Hirohashi, S Hirano, M Noguchi… - Cancer research, 1989 - AACR
Two distinct calcium-sensitive cell-cell adhesion molecules were identified in human
epithelial tissues and carcinomas using two monoclonal antibodies raised against vulvar
epidermoid carcinoma A-431 and human mammary carcinoma MCF-7 and selected on the …

M Sakamoto, S Hirohashi, Y Shimosato - Human pathology, 1991 - Elsevier
From a series of 320 heptocellular carcinoma (HCC) cases treated surgically, we selected
small nodular lesions that had not destroyed the preexisting liver structure grossly. After
excluding metastases and large regenerative nodules, 58 lesions from 41 cases were …

S Hirano, N Kimoto, Y Shimoyama, S Hirohashi… - Cell, 1992 - Elsevier
The function of cadherin cell adhesion molecules is thought to be regulated by a group of
cytoplasmic proteins, including α-catenin. We identified a subtype of α-catenin, termed αN-
catenin, which is associated with N-cadherin and expressed mainly in the nervous system …

N Hiraoka, K Onozato, T Kosuge, S Hirohashi - Clinical Cancer Research, 2006 - AACR
Purpose: Antitumor immune response changes drastically during the progression of
cancers. Established cancers often escape from the host immune system, although specific
immune surveillance operates in the early stages of tumorigenesis in murine models. CD4+ …

…, H Hasegawa, N Okazaki, K Takayasu, S Hirohashi… - The Lancet, 1990 - Elsevier
To clarify the course of adenomatous hyperplasia (AH) of the liver, 17 patients with 20
biopsy-proven AH nodules were followed clinically for 1-5 years. At the initial biopsy the
mean nodular diameter was 10 (SD 4) mm and the relative cellularity ([mean cellularity of …

…, H Tsuda, M Sakamoto, S Hirohashi - … journal of cancer, 1997 - Wiley Online Library
Our study was designed to clarify the significance of silencing the E‐cadherin gene, which is
located on 16q22. 1, due to CpG methylation during hepatocarcinogenesis. The CpG
methylation status of primary hepatocellular carcinomas (HCCs) and corresponding liver …